Prolia (denosumab)

Prolia® is a prescription medicine used to treat osteoporosis (thinning and weakening of bone) in women after menopause who:

Have an increased risk for fractures (broken bones).
Cannot use another osteoporosis medicine or other osteoporosis medicines did not work well.

Prolia® isn’t right for everyone. Do not take Prolia® if you have been told by your doctor that your blood calcium level is too low. You should take calcium and vitamin D as your doctor tells you to while you receive Prolia®.

What is the most important information I should know about Prolia®?

If you receive Prolia®, you should not receive XGEVA®. Prolia® contains the same medicine as XGEVA® (denosumab).

Prolia® can cause serious side effects:

Low calcium levels in your blood (hypocalcemia). Prolia® may lower the calcium levels in your blood. If you have low blood calcium, it may get worse during treatment. Your low blood calcium must be treated before you receive Prolia®.

Your doctor may prescribe calcium and vitamin D to help prevent low calcium levels in your blood. Take calcium and vitamin D as your doctor tells you to.

Serious infections. Serious infections in your skin, lower stomach area (abdomen), bladder, or ear may happen. Inflammation of the inner lining of the heart (endocarditis) due to an infection may also happen more often in people who take Prolia®. You may need to go to the hospital for treatment.

Prolia® is a medicine that may affect your immune system. People who have weakened immune systems or take medicines that affect the immune system may have an increased risk for developing serious infections.

Skin problems. Skin problems such as inflammation of your skin (dermatitis), rash, and eczema have been reported.

Severe jaw bone problems (osteonecrosis). Severe jaw bone problems may occur. Your doctor should examine your mouth before you start Prolia® and may tell you to see your dentist. It is important for you to practice good mouth care during treatment with Prolia®

What are the possible side effects of Prolia®?

It is not known if the use of Prolia® over a long period of time may cause slow healing of broken bones or unusual fractures. The most common side effects of Prolia® are back pain, pain in your arms and legs, high cholesterol, muscle pain, and bladder infection.

These are not all the possible side effects of Prolia®. For more information, ask your doctor or pharmacist. Call your doctor for medical advice about side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit, or call 1-800-FDA-1088.

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Phyllis Beshell

I am being urged by an orthopedic Dr. and primary care physician to start Prolia. My Chiropractor is against it. I am a 90 year old woman who exercises and does yoga once a week. Have been going to a gym for 35 years, yet my bone density is not good. I have tried Forteo, Boniva, and now an on a regimen of Calicium and Grow Bone through a health food industry. plus vitamin D3. Am in such a quandry about Prolia because of all the possible side effects and do believe Boniva caused some jaw pain and I had to have two crowns. Any suggestions?

Phyllis Beshell

Would like to see some reviews of others who are on Prolia


I had my first injection of Prolia 5 months ago & due for a 2nd one in June. I do not intend to get the 2nd shot, as this has been one long miserable ride. – Am high risk osteoprosis & went to a Chiropractor *telling him about the osteoprosis!* – He did not listen…. Went to him ONLY for a migraine that would not heal after 2 months of suffering with it. (Ended up with Compression Fractures in the back that felt like someone held an electric cattle prod on the spine) – Then got a bad infection in the spine & ended up in the hospital for over 2 weeks. – - The pain lessened in the back pretty much UNTIL the Prolia Injection! Now it is excruciating & will not let up (Especially walking or a bra strap across the upper back). > Pain won’t stop! . . Am clenching jaw often & miserable…. (Kind of afraid of what might happen if osteo is let go, but also more concerned now about the side effects & not knowing the long term effects of Prolia).-Dexa next month, so will see if there is any improvement….. If there IS IMPROVEMENT, Might take another shot (but highly doubt it)…. Not enough studies & I feel like we women are being used as lab rats… Soon, they will see how many women suffered or gained from it & release their findings…. Hope it is not bad news, like it was with Boniva, which I also took for 4 years , to no avail… It did not help & was horrible. Thank You. – Would like to know more on how other’s are handling this, as well.

Betty Salvans

DO NOT TAKE PROLIA. This is an awful medicine. Took the first injection and the next day and ever since, back and shoulder pain. Now Im taking VICODIN which is highly addictive. FDA, please take this drug off the mattket.

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